KLRC4 - killer cell lectin like receptor C4 Gene
Also Known as NKG2F; NKG2-F
生物種: Homo sapiens
About KLRC4
This gene has 1 transcript (splice variant), 368 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 6.6), lymph node (RPKM 3.0) and 17 other tissues.
Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]
KLRC4 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_013431.2 | NP_038459.1 | NKG2-F type II integral membrane protein |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NKG2-F type II integral membrane protein |
|
関連疾患
| Diseases | Alias | |
|---|---|---|
| Behcet Syndrome |
|
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| Immunodeficiency 31a |
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| Immunodeficiency 31c |
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| Aphthous Stomatitis |
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