DRC7 - dynein regulatory complex subunit 7 Gene

Also Known as FAP50; CFAP50; CCDC135; C16orf50

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 84229

About DRC7

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,694,806-57,731,805 (from NCBI)

This gene has 10 transcripts (splice variants) and 139 orthologues. Restricted expression toward testis (RPKM 24.8).

Summary

Predicted to be involved in flagellated sperm motility. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DRC7 Products (3)

mRNA	Protein	Name
NM_001289162.2	NP_001276091.1	dynein regulatory complex subunit 7 isoform a
NM_001289163.2	NP_001276092.1	dynein regulatory complex subunit 7 isoform b
NM_032269.6	NP_115645.4	dynein regulatory complex subunit 7 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	24407287	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dynein regulatory complex subunit 7	coiled-coil domain containing 135

DRC7 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DRC7	Q8IY82	MBIP	Homo sapiens	Q9NS73-5	Y2H Prey Pooling	25416956
Intra	DRC7	Q8IY82	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	DRC7	Q8IY82	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	DRC7	Q8IY82	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	DRC7	Q8IY82	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	DRC7	Q8IY82	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	DRC7	Q8IY82	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	DRC7	Q8IY82	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	DRC7	Q8IY82	DLST	Homo sapiens	P36957	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 2 PKD2 Polycystic Kidney Disease, Adult, Type Ii Apkd2 Polycystic Kidney Disease, Type 2 Adpkd2 Adult Polycystic Kidney Disease Type 2 Autosomal Dominant Polycystic Kidney Disease 2 Pkd-2 Polycystic Kidney Disease Adult Type Ii Polycystic Kidney Type 2 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 2
Bardet-Biedl Syndrome 1	BBS1 Bardet-Biedl Syndrome 1, Modifier Of Bardet-Biedl Syndrome BBS Bardet-Biedl Syndrome, Type 1 Laurence-Moon-Bardet-Biedl Syndrome
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03993	DRC7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	DRC7	VGNC	VGNC:61625
Bos taurus	DRC7	VGNC	VGNC:28206
Macaca mulatta	DRC7	VGNC	VGNC:71905
Canis familiaris	DRC7	VGNC	VGNC:40092
Rattus norvegicus	DRC7	RGD	RGD:1565601
Mus musculus	DRC7	MGD	MGI:2685616
Others	DRC7	NCBI