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DLG5 - discs large MAGUK scaffold protein 5 Gene

Also Known as PDLG; LP-DLG; P-DLG5

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9231

About DLG5

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:77,790,791-77,940,736 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 268 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 23.0), skin (RPKM 17.3) and 22 other tissues.

Summary

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the Cytoskeleton. It is proposed to function in the transmission of extracellular signals to the Cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

DLG5 Products (1)

mRNA	Protein	Name
NM_004747.4	NP_004738.3	disks large homolog 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables beta-catenin binding	IDA IDA: Inferred from direct assay	12657639	GOA
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	12657639	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23624079	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	28169360	GOA
involved in maintenance of cell polarity	IMP IMP: Inferred from mutant phenotype	28169360	GOA
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	28169360	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	28169360	GOA
involved in negative regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	28087714	GOA
involved in positive regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	28169360	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cell junction	IDA IDA: Inferred from direct assay	28169360	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLG5 Protein Structure

Takusan

PDZ

Guanylate_kin

0
300
600
900
1200
1500
1800
1919 a.a.

Protein Preferred Names	Protein Names
disks large homolog 5	discs large protein LP-DLG

DLG5 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Cross	DLG5	Q8TDM6	Tgfbr2	Mus musculus	Q62312	IF	23624079
Cross	DLG5	Q8TDM6	Tgfbr2	Mus musculus	Q62312	Anti Tag CoIP	23624079
Cross	DLG5	Q8TDM6	Tgfbr1	Mus musculus	Q64729	IF	23624079
Cross	DLG5	Q8TDM6	Tgfbr1	Mus musculus	Q64729	Anti Tag CoIP	23624079

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Inflammatory Bowel Disease 5	IBD5
Anorectal Stricture	Stenosis Of Rectum And Anus Anorectal Malformations
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03800	DLG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	DLG5	MGD	MGI:1918478
Bos taurus	DLG5	VGNC	VGNC:28087
Rattus norvegicus	DLG5	RGD	RGD:1308753
Felis catus	DLG5	VGNC	VGNC:61513
Canis familiaris	DLG5	VGNC	VGNC:50873
Macaca mulatta	DLG5	VGNC	VGNC:71921