FEM1B - fem-1 homolog B Gene

Also Known as F1AA; F1A-ALPHA; FEM1-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10116

About FEM1B

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,277,745-68,295,862 (from NCBI)

This gene has 4 transcripts (splice variants), 113 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 18.1), endometrium (RPKM 14.9) and 25 other tissues.

Summary

This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating Apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

FEM1B Products (1)

mRNA Protein Name
NM_015322.5 NP_056137.1 protein fem-1 homolog B

FEM1B Protein Structure

Ank

Ank: Ankyrin repeat (48 - 68)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (92 - 183)

Ank

Ank: Ankyrin repeat (187 - 209)

Ank

Ank: Ankyrin repeat (218 - 241)

Ank

Ank: Ankyrin repeat (484 - 530)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 627 a.a.
Protein Preferred Names Protein Names

protein fem-1 homolog B

  • FEM-1-like death receptor binding protein

FEM1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FEM1B Q9UK73 PPM1F Homo sapiens P49593
Pull Down
11559703
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type C Thymoma

  • Thymoma, Type C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168865 E3 ligase Ligand 53 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FEM1B VGNC VGNC:72634
Canis familiaris FEM1B VGNC VGNC:40816
Bos taurus FEM1B VGNC VGNC:28945
Mus musculus FEM1B MGD MGI:1335087
Felis catus FEM1B VGNC VGNC:104392
Rattus norvegicus FEM1B RGD RGD:1304569
Others FEM1B NCBI