Slc34a1 - solute carrier family 34 member 1 Gene

Also Known as Npt2; NaPi-2; NaPi2A; Slc17a2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25548

Summary

Enables PDZ domain binding activity and identical protein binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; ion transmembrane transport; and regulation of phosphate transport. Located in several cellular components, including apical plasma membrane; brush border membrane; and membrane raft. Is intrinsic component of plasma membrane. Biomarker of autosomal dominant polycystic kidney disease; chronic kidney disease (multiple); hyperthyroidism; hypophosphatemia; and hypothyroidism. Human ortholog(s) of this gene implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. Orthologous to human SLC34A1 (solute carrier family 34 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc34a1 Products (1)

mRNA Protein Name
NM_013030.2 NP_037162.1 sodium-dependent phosphate transport protein 2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15917299 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9163330 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21372499 RGD
enables sodium:phosphate symporter activity IDA
IDA: Inferred from direct assay
8327470 RGD
enables sodium:phosphate symporter activity IMP
IMP: Inferred from mutant phenotype
10926678 RGD
Biological Process GO Annotation Evidence References Source
involved in arsenate ion transmembrane transport IDA
IDA: Inferred from direct assay
20510259 RGD
involved in cellular response to metal ion IEP
IEP: Inferred from expression pattern
16476458 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
16767692 RGD
involved in cellular response to phosphate starvation IDA
IDA: Inferred from direct assay
9058191 RGD
involved in cellular response to staurosporine IEP
IEP: Inferred from expression pattern
10332085 RGD
involved in dentinogenesis IEP
IEP: Inferred from expression pattern
12369784 RGD
involved in gentamycin metabolic process IEP
IEP: Inferred from expression pattern
11231357 RGD
involved in glycoprotein metabolic process IEP
IEP: Inferred from expression pattern
19005008 RGD
involved in indole metabolic process IEP
IEP: Inferred from expression pattern
10332085 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
10405196 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
17310099 RGD
involved in phosphate ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
8327470 RGD
involved in positive regulation of membrane potential IDA
IDA: Inferred from direct assay
11880379 RGD
involved in positive regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
11880330 RGD
involved in positive regulation of phosphate transmembrane transport IDA
IDA: Inferred from direct assay
20236253 RGD
involved in positive regulation of sodium-dependent phosphate transport IDA
IDA: Inferred from direct assay
12739158 RGD
involved in positive regulation of sodium-dependent phosphate transport IEP
IEP: Inferred from expression pattern
16476458 RGD
involved in positive regulation of sodium-dependent phosphate transport IMP
IMP: Inferred from mutant phenotype
11880379 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18305465 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
14996669 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
18701629 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
10027934 RGD
involved in response to parathyroid hormone IEP
IEP: Inferred from expression pattern
20526720 RGD
involved in response to peptide IEP
IEP: Inferred from expression pattern
11532101 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15581846 RGD
involved in response to potassium ion IEP
IEP: Inferred from expression pattern
19493963 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
10098486 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
20507281 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
22260362 RGD
involved in sodium ion import across plasma membrane IDA
IDA: Inferred from direct assay
8327470 RGD
involved in sodium-dependent phosphate transport IEP
IEP: Inferred from expression pattern
17310099 RGD
involved in tricarboxylic acid metabolic process IEP
IEP: Inferred from expression pattern
10926678 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
9639577 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
8691716 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21865732 RGD
located in endosome IDA
IDA: Inferred from direct assay
16514432 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10449440 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
10370077 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium-dependent phosphate transport protein 2A

  • Na(+)-dependent phosphate cotransporter 2A

  • Na(+)/Pi cotransporter 2A

  • naPi-2a

  • sodium-phosphate co-transporter type II

  • sodium-phosphate transport protein 2A

  • sodium/phosphate cotransporter 2A

  • solute carrier family 17 (sodium/hydrogen exchanger) member

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112065 PF-06869206 Inhibitor 99.88% Unkown
HY-RS13192 SLC34A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc34a1 NCBI NCBI:6569