GUCA1B - guanylate cyclase activator 1B Gene

Also Known as RP48; GCAP2; GUCA2; GCAP 2; GCAP-2; GCAP-II

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 2979

Summary

The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]

GUCA1B Products (1)

mRNA Protein Name
NM_002098.6 NP_002089.4 guanylyl cyclase-activating protein 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cone photoreceptor outer segment IDA
IDA: Inferred from direct assay
9620085 GOA
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
9620085 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylyl cyclase-activating protein 2

  • guanylate cyclase activator 1B (retina)

  • guanylate cyclase-activating protein, photoreceptor 2

GUCA1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GUCA1B Q9UMX6 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
GUCA1B Q9UMX6 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05915 GUCA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05917 GUCA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19509 Guca1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26003 Guca1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown