SYTL1 - synaptotagmin like 1 Gene

Also Known as JFC1; SLP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84958

About SYTL1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,342,022-27,353,932 (from NCBI)

This gene has 11 transcripts (splice variants), 176 orthologues and 31 paralogues. Broad expression in prostate (RPKM 24.6), skin (RPKM 21.7) and 16 other tissues.

Summary

Predicted to enable neurexin family protein binding activity. Involved in exocytosis. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYTL1 Products (2)

mRNA Protein Name
NM_001193308.2 NP_001180237.1 synaptotagmin-like protein 1 isoform 1
NM_032872.3 NP_116261.1 synaptotagmin-like protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18266782 GOA
Biological Process GO Annotation Evidence References Source
involved in exocytosis IDA
IDA: Inferred from direct assay
18266782 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
18266782 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYTL1 Protein Structure

C2

C2: C2 domain (283 - 367)

C2

C2: C2 domain (424 - 509)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 562 a.a.
Protein Preferred Names Protein Names

synaptotagmin-like protein 1

  • NADPH oxidase-related, C2 domain-containing protein

Related Diseases

Diseases Alias
Severe Congenital Neutropenia 7

  • Autosomal Recessive Severe Congenital Neutropenia Due To Csf3r Deficiency

  • Scn7
Joubert Syndrome 30

  • JBTS30

  • Joubert Syndrome, Type 30
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14122 SYTL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SYTL1 VGNC VGNC:53476
Rattus norvegicus SYTL1 RGD RGD:1310715
Macaca mulatta SYTL1 VGNC VGNC:78122
Bos taurus SYTL1 VGNC VGNC:35546
Mus musculus SYTL1 MGD MGI:1933365
Felis catus SYTL1 VGNC VGNC:65905