Diterpenoids from Isodon melissoides

  • J Nat Prod. 2004 Sep;67(9):1441-4. doi: 10.1021/np030418l.
Ai-Hua Zhao  1 ,  Quan-Bin Han ,  Rong-Tao Li ,  Sheng-Hong Li ,  Chen Qing ,  Yan-Li Zhang ,  Qin-Shi Zhao ,  Fu-Sheng Wang ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 15387638 DOI: 10.1021/np030418l
Abstract

Nine new Diterpenoids, melissoidesins M-U (1-9), along with five known analogues, melissoidesin F (10), xindongnin B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides. The structures of new compounds were elucidated by analysis of spectral evidence including extensive 2D NMR data. Compounds 2, 3, 7, 11, 12, and 14 showed cytotoxicity against the human tumor BGC-823 cell line with IC(50) values less than 10 microg/mL, respectively.