Lanostane-type triterpenoids from the roots of Kadsura coccinea

  • J Nat Prod. 2008 Jun;71(6):990-4. doi: 10.1021/np7007522.
Nan Wang  1 ,  Zhanlin Li ,  Dandan Song ,  Wei Li ,  Hongwei Fu ,  Kazuo Koike ,  Yuehu Pei ,  Yongkui Jing ,  Huiming Hua
Affiliations
  • 1. Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
PMID: 18491866 DOI: 10.1021/np7007522
Abstract

Seven new lanostane-type triterpenoids, seco-coccinic acids A-F (1- 6) and coccinilactone A (7), were isolated from the roots of Kadsura coccinea. Their structures were established on the basis of spectroscopic data analysis. The absolute configuration at C-24 of compound 5 was confirmed by the modified Mosher's method. The cell growth inhibitory effects of these compounds were determined in human leukemia HL-60 cells, and it was found that compounds 1, 2, 3, and 5 exhibited antiproliferative effects with GI 50 values ranging from 6.8 to 42.1 microM.