Potential anti-allergic acridone alkaloids from the roots of Atalantia monophylla

  • Phytochemistry. 2008 Oct;69(14):2616-20. doi: 10.1016/j.phytochem.2008.08.007.
Arnon Chukaew  1 ,  Chanita Ponglimanont ,  Chatchanok Karalai ,  Supinya Tewtrakul
Affiliations
  • 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
PMID: 18817938 DOI: 10.1016/j.phytochem.2008.08.007
Abstract

Acridone Alkaloids, cycloatalaphylline-A (1), N-methylcyclo-atalaphylline-A (2) and N-methylbuxifoliadine-E (3), were isolated from the dichloromethane and acetone extracts of the root of Atalantia monophylla along with eight known acridone alkaloids: buxifoliadine-A (4), buxifoliadine-E (5), N-methylatalaphylline (6), atalaphylline (7), citrusinine-I (8), N-methylataphyllinine (9), yukocitrine (10) and junosine (11) and two known coumarins: auraptene (12) and 7-O-geranylscopoletin (13). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 2, 5 and 8 possessed appreciable anti-allergic activity in RBL-2H3 cells model with IC(50) values of 40.1, 6.1 and 18.7 microM, respectively.

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