124750-95-4
Chemical Structure
DuP-532
- CAS No.: 124750-95-4
- Formula:C23H19F5N6O2
- Molecular Weight:506.43
IUPAC Name: 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(perfluoroethyl)-2-propyl-1H-imidazole-5-carboxylic acid
InChIKey: RQGDXPDTZWGCQI-UHFFFAOYSA-N
SMILES: O=C(C1=C(C(F)(C(F)(F)F)F)N=C(CCC)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)O
Biological Activity: DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction[1].
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DuP-532 | 98.00% | DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction. | ||||||||||||||||||||
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Keywords
