572874-50-1
572874-50-1
Chemical Structure
Laropiprant sodium
Synonym(s): MK-0524 sodium
- CAS No.: 572874-50-1
- Formula:C21H18ClFNNaO4S
- Molecular Weight:457.88
IUPAC Name: sodium (R)-2-(4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate
InChIKey: DWCYUNBVZHNVET-BTQNPOSSSA-M
SMILES: O=S(C1=CC(F)=CC2=C1N(C3=C2CC[C@@H]3CC(O[Na])=O)CC4=CC=C(Cl)C=C4)(C)=O
Biological Activity: Laropiprant sodium is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively[1][2][3].
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Laropiprant sodium | Laropiprant sodium is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively. | |||||||||||||||||||||
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References
- [1]. Labrecque P, et, al. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One. 2013 Jun 10;8(6):e65767.
- [2]. Sturino CF, et, al. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J Med Chem. 2007 Feb 22;50(4):794-806. [Content Brief]
- [3]. Chang SW, et, al. The pharmacokinetics and disposition of MK-0524, a Prosglandin D2 Receptor 1 antagonist, in rats, dogs and monkeys. Xenobiotica. 2007 May;37(5):514-33. [Content Brief]
Keywords
