Add1 - adducin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24170

Summary

Enables T cell receptor binding activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of actin filament polymerization; and positive regulation of angiogenesis. Located in dendritic spine; perinuclear region of cytoplasm; and postsynaptic density. Used to study hypertension. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Apr 2022]

Add1 Products (1)

mRNA Protein Name
NM_016990.2 NP_058686.2 alpha-adducin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables T cell receptor binding IDA
IDA: Inferred from direct assay
15163540 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7592723 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to retinoic acid IDA
IDA: Inferred from direct assay
20493242 RGD
involved in negative regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
8675693 RGD
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
17512505 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
18524856 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
8624703 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
8624703 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20493242 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-adducin

  • adducin 1 (alpha)

  • alpha-ADD

  • erythrocyte adducin subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00338 ADD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17721 Srebf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24186 Srebf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Add1 NCBI NCBI:118