2. Academic Validation
  3. Synthesis and biological evaluation of DNA targeting flexible side-chain substituted beta-carboline derivatives

Synthesis and biological evaluation of DNA targeting flexible side-chain substituted beta-carboline derivatives

  • Bioorg Med Chem Lett. 2001 Feb 26;11(4):437-41. doi: 10.1016/s0960-894x(00)00679-x.
S Xiao 1,  W Lin,  C Wang,  M Yang
Affiliations

Affiliation

  • 1 National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People's Republic of China.
PMID: 11229742 DOI: 10.1016/s0960-894x(00)00679-x
Abstract

A series of 3-substituted-beta-carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating ability and their antitumor activity were studied, which agreed well with the molecular modeling results.

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