2. Academic Validation
  3. Cytotoxic hydrolyzable tannins from Balanophora japonica

Cytotoxic hydrolyzable tannins from Balanophora japonica

  • J Nat Prod. 2008 Apr;71(4):719-23. doi: 10.1021/np070519+.
Zhi-Hong Jiang 1,  Xiao-Yun Wen,  Takashi Tanaka,  Shao-Yu Wu,  Zhongqiu Liu,  Hiromi Iwata,  Yoko Hirose,  Shuguang Wu,  Isao Kouno
Affiliations

Affiliation

  • 1 School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, People's Republic of China. [email protected]
PMID: 18302336 DOI: 10.1021/np070519+
Abstract

Four hydrolyzable tannins named balanophotannins D-G ( 1- 4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D ( 1) and F ( 3) were determined via the PGME method. Balanophotannin E ( 2) showed cytotoxicity to Hep G2 Cancer cells with an IC 50 value of 4.22 microM.

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