Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth

  • Eur J Med Chem. 2014 May 22:79:95-101. doi: 10.1016/j.ejmech.2014.03.087.
Xue-Wen Zhou  1 ,  Han-Lin Ma  2 ,  Xuan Zhang  1 ,  Shi-Yao Jing  1 ,  Jun-Ying Miao  3 ,  Bao-Xiang Zhao  4
Affiliations
  • 1. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
  • 2. Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, PR China.
  • 3. Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, PR China. Electronic address: [email protected].
  • 4. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China. Electronic address: [email protected].
PMID: 24727462 DOI: 10.1016/j.ejmech.2014.03.087
Abstract

A series of novel 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives was synthesized. The structures of compounds were characterized by (1)H NMR, IR, and MS. Moreover, representative crystal structure was determined by X-ray diffraction analysis. The preliminary biological evaluation of all these compounds showed that compounds 3a-3d would suppress the growth of A549 lung cells effectively by inducing Autophagy and cell cycle arrest.

Keywords
A549 lung cells; Autophagy; Benzoxazinone; Chalcone.