Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002

  • J Nat Prod. 2018 Apr 27;81(4):1045-1049. doi: 10.1021/acs.jnatprod.7b00673.
Cai-Juan Zheng  1 ,  Meng Bai  1 ,  Xue-Ming Zhou  1 ,  Guo-Lei Huang  1 ,  Tai-Ming Shao  2 ,  You-Ping Luo  1 ,  Zhi-Gang Niu  1 ,  Yan-Yan Niu  1 ,  Guang-Ying Chen  1 ,  Chang-Ri Han  2
Affiliations
  • 1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering , Hainan Normal University , Haikou , Hainan 571158 , People's Republic of China.
  • 2. Hainan Institute of Science and Technology , Haikou 571126 , People's Republic of China.
PMID: 29489361 DOI: 10.1021/acs.jnatprod.7b00673
Abstract

Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and Antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.