123-82-0
Chemical Structure
2-Aminoheptane
Synonym(s): Tuaminoheptane
- CAS No.: 123-82-0
- Formula:C7H17N
- Molecular Weight:115.22
IUPAC Name: heptan-2-amine
InChIKey: VSRBKQFNFZQRBM-UHFFFAOYSA-N
SMILES: CC(N)CCCCC
Biological Activity: 2-Aminoheptane (Tuaminoheptane) is a norepinephrine transporter inhibitor. 2-Aminoheptane binds to norepinephrine transporter via ionic and hydrophobic interactions to block norepinephrine uptake. 2-Aminoheptane deactivates ω-TAmla enzyme, reduces recombinant whole cell stability, and acts as an amino group donor substrate for ω-TA and ω-TAmla enzymes. 2-Aminoheptane can be used in research on depression and Alzheimer's disease[1][2][3][4].
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2-Aminoheptane | 99.69% | 2-Aminoheptane (Tuaminoheptane) is a norepinephrine transporter inhibitor. 2-Aminoheptane binds to norepinephrine transporter via ionic and hydrophobic interactions to block norepinephrine uptake. 2-Aminoheptane deactivates ω-TAmla enzyme, reduces recombinant whole cell stability, and acts as an amino group donor substrate for ω-TA and ω-TAmla enzymes. 2-Aminoheptane can be used in research on depression and Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Schlessinger A, et al. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A. 2011;108(38):15810-15815. [Content Brief]
- [2]. Zaremba I, et al. Differentiation of isomeric heptylamines by in-source collision-induced dissociation of [M + H]+ ions. Rapid Commun Mass Spectrom. 2019;33(9):848-856. [Content Brief]
- [3]. Yun H, et al. Use of enrichment culture for directed evolution of the Vibrio fluvialis JS17 omega-transaminase, which is resistant to product inhibition by aliphatic ketones. Appl Environ Microbiol. 2005;71(8):4220-4224. [Content Brief]
- [4]. Cogo A, et al. Efficacy of topical tuaminoheptane combined with N-acetyl-cysteine in reducing nasal resistance. A double-blind rhinomanometric study versus xylometazoline and placebo. Arzneimittelforschung. 1996;46(4):385-388. [Content Brief]
Keywords
