Wfs1 - wolframin ER transmembrane glycoprotein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83725

Summary

Enables several functions, including Calmodulin binding activity; Proteasome binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of ATF6-mediated unfolded protein response; protein stabilization; and regulation of transcription, DNA-templated. Is integral component of synaptic vesicle membrane. Used to study cataract; diabetes mellitus; and glucose intolerance. Biomarker of post-traumatic stress disorder and visual epilepsy. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER Transmembrane Glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Wfs1 Products (1)

mRNA Protein Name
NM_031823.1 NP_114011.1 wolframin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20160352 RGD
enables calcium-dependent protein binding IMP
IMP: Inferred from mutant phenotype
19292454 RGD
enables calmodulin binding IMP
IMP: Inferred from mutant phenotype
19292454 RGD
enables proteasome binding IDA
IDA: Inferred from direct assay
20160352 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ATF6-mediated unfolded protein response IGI
IGI: Inferred from genetic interaction
20160352 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20160352 RGD
involved in olfactory behavior IEP
IEP: Inferred from expression pattern
11958857 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
19916172 RGD
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20160352 RGD
Cellular Component GO Annotation Evidence References Source
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
17110340 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
17110340 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

wolframin

  • Wolfram syndrome 1 (wolframin)

  • Wolfram syndrome 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137605 WSF1-IN-1 Inhibitor 99.91% Unkown
HY-181649 S1R agonist 3 Agonist / Unkown
HY-RS15813 WFS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18644 Wfs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25129 Wfs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wfs1 NCBI NCBI:7466