Endothelin-1: a multifunctional molecule in cancer
- Br J Cancer. 2003 Jan 27;88(2):163-6. doi: 10.1038/sj.bjc.6700750.
Affiliations
- 1. Department of Surgery, Royal Free and University College London Medical School, UK.
PMID: 12610497
DOI: 10.1038/sj.bjc.6700750
Abstract
Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, Apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an Adjuvant therapeutic strategy.
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