2143104-11-2
Chemical Structure
EGFR T790M/FAK-IN-2
- CAS No.: 2143104-11-2
- Formula:C25H28ClN7O3
- Molecular Weight:510.00
IUPAC Name: 2-((5-chloro-2-((3-methyl-4-(2-morpholinoacetamido)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
InChIKey: IWCUHRIIUCIMLP-UHFFFAOYSA-N
SMILES: O=C(NC)C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(NC(=O)CN4CCOCC4)C(=C3)C
Biological Activity: EGFR T790M/FAK-IN-2 is an orally active dual FAK and EGFRT790M kinase inhibitor, with an IC50 of 1.03 nM against FAK and an IC50 of 3.89 nM against EGFRT790M. EGFR T790M/FAK-IN-2 exerts antiproliferative effects in drug-resistant cancer cells overexpressing FAK, inducing apoptosis and cell cycle arrest. EGFR T790M/FAK-IN-2 exhibits antitumor activity in a pancreatic cancer xenograft mouse model. EGFR T790M/FAK-IN-2 can be used for the research of pancreatic cancer, breast cancer and non-small cell lung cancer[1].
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EGFR T790M/FAK-IN-2 | EGFR T790M/FAK-IN-2 is an orally active dual FAK and EGFRT790M kinase inhibitor, with an IC50 of 1.03 nM against FAK and an IC50 of 3.89 nM against EGFRT790M. EGFR T790M/FAK-IN-2 exerts antiproliferative effects in drug-resistant cancer cells overexpressing FAK, inducing apoptosis and cell cycle arrest. EGFR T790M/FAK-IN-2 exhibits antitumor activity in a pancreatic cancer xenograft mouse model. EGFR T790M/FAK-IN-2 can be used for the research of pancreatic cancer, breast cancer and non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
