498-95-3
498-95-3
Chemical Structure
Nipecotic acid
Synonym(s): (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine
- CAS No.: 498-95-3
- Formula:C6H11NO2
- Molecular Weight:129.16
IUPAC Name: piperidine-3-carboxylic acid
InChIKey: XJLSEXAGTJCILF-UHFFFAOYSA-N
SMILES: O=C(C1CNCCC1)O
Biological Activity: Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2].
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Nipecotic acid | 97.0% | Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM. | ||||||||||||||||||||
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Nipecotic acid (Standard) | ≥98% | Nipecotic acid (Standard) is the analytical standard of Nipecotic acid. This product is intended for research and analytical applications. Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM. | ||||||||||||||||||||
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References
- [1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8. [Content Brief]
- [2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103. [Content Brief]
