ZCCHC4 - zinc finger CCHC-type containing 4 Gene

Also Known as ZGRF4; HSPC052

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29063

About ZCCHC4

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,312,774-25,370,383 (from NCBI)

This gene has 5 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.3) and 25 other tissues.

Summary

Enables S-adenosyl-L-methionine binding activity; rRNA (adenine-N6-)-methyltransferase activity; and zinc ion binding activity. Involved in positive regulation of translation and rRNA methylation. Located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ZCCHC4 Products (2)

mRNA Protein Name
NM_001318148.2 NP_001305077.1 rRNA N6-adenosine-methyltransferase ZCCHC4 isoform 2
NM_024936.3 NP_079212.2 rRNA N6-adenosine-methyltransferase ZCCHC4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
31695039 GOA
enables rRNA (adenine-N6-)-methyltransferase activity IDA
IDA: Inferred from direct assay
30531910 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
31695039 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of translation IDA
IDA: Inferred from direct assay
30531910 GOA
involved in rRNA methylation IDA
IDA: Inferred from direct assay
30531910 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
30531910 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
30531910 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZCCHC4 Protein Structure

zf-GRF

zf-GRF: GRF zinc finger (38 - 82)

N6-adenineMlase

N6-adenineMlase: Probable N6-adenine methyltransferase (171 - 294)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
Protein Preferred Names Protein Names

rRNA N6-adenosine-methyltransferase ZCCHC4

  • DHHC domain-containing zinc finger protein

Related Diseases

Diseases Alias
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16005 ZCCHC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21978 Zcchc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28495 Zcchc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZCCHC4 VGNC VGNC:79358
Rattus norvegicus ZCCHC4 RGD RGD:1311414
Canis familiaris ZCCHC4 VGNC VGNC:48570
Felis catus ZCCHC4 VGNC VGNC:67197
Bos taurus ZCCHC4 VGNC VGNC:37120
Mus musculus ZCCHC4 MGD MGI:1926046