1 Result for "

pd098059

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "pd098059" in MCE Product Catalog:

395
395 Cited Publications
Cat. No.: HY-12028
CAS No.: 167869-21-8
Purity:  98.89%
Research Areas:  

Cancer

PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .