2 Results for "

vidutolimod

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "vidutolimod" in MCE Product Catalog:

Vidutolimod
Vidutolimod
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Cat. No.: HY-148511
CAS No.: 147063-80-7
Synonyms: CMP-001
Target:  

Toll-like Receptor (TLR) IFNAR PD-1/PD-L1 Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:  

Cancer

Vidutolimod (CMP-001) is a virus-like particle containing a TLR9 activator . Vidutolimod induces human peripheral blood mononuclear cells to secrete IFNα, and upregulates the gene expression of CXCL10, PDL1, IDO and CD80. Vidutolimod activates TLR9, which in turn triggers plasmacytoid dendritic cell activation, production of IFNγ and TNFα, induction of CXCL10, and recruitment of antitumor T cells. Vidutolimod causes influenza-like symptoms, hypotension and tumor regression, and its activity depends on the presence of anti-Qβ antibodies. Vidutolimod modulates monocyte function, promotes CD4 T cell proliferation, and activates multiple immune cell types in an environment with anti-Qβ antibodies. Vidutolimod prolongs the survival of tumor-bearing mice. Vidutolimod is used in research related to advanced melanoma, head and neck squamous cell carcinoma, and advanced non-small cell lung cancer .
Vidutolimod sodium
Vidutolimod sodium
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Cat. No.: HY-148511A
Purity:  90.20%
Synonyms: CMP-001 sodium
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Cancer

Vidutolimod sodium is a CpG-A oligodeoxynucleotide. Vidutolimod sodium is a Toll-like receptor 9 (TLR9) agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects.
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