MICALL2 - MICAL like 2 Gene

Also Known as JRAB; MICAL-L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79778

About MICALL2

This gene has 15 transcripts (splice variants), 255 orthologues and 7 paralogues. Broad expression in spleen (RPKM 13.4), small intestine (RPKM 10.9) and 23 other tissues.

Summary

Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; neuron projection; and recycling endosome. Predicted to colocalize with stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

MICALL2 Products (1)

mRNA Protein Name
NM_182924.4 NP_891554.1 MICAL-like protein 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables filamin binding IDA
IDA: Inferred from direct assay
23890175 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICALL2 Protein Structure

CH

CH: Calponin homology (CH) domain (6 - 106)

LIM

LIM: LIM domain (188 - 241)

DUF3585

DUF3585: Protein of unknown function (DUF3585) (736 - 872)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 904 a.a.
Protein Preferred Names Protein Names

MICAL-like protein 2

  • junctional Rab13-binding protein

MICALL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MICALL2 Q8IY33 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
MICALL2 Q8IY33 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
MICALL2 Q8IY33 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
MICALL2 Q8IY33 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
MICALL2 Q8IY33 CDR2 Homo sapiens Q01850
Validated Y2H
32296183
Intra
MICALL2 Q8IY33 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
MICALL2 Q8IY33 ACTN3 Homo sapiens Q08043
Y2H Array
32296183
Intra
MICALL2 Q8IY33 ACTN3 Homo sapiens Q08043
Y2H Prey Pooling
32296183
Intra
MICALL2 Q8IY33 ACTN4 Homo sapiens O43707
Y2H Prey Pooling
32296183
Intra
MICALL2 Q8IY33 ACTN4 Homo sapiens O43707
Y2H Array
32296183
Intra
MICALL2 Q8IY33 ACTN1 Homo sapiens P12814
Y2H Array
32296183
Intra
MICALL2 Q8IY33 ACTN1 Homo sapiens P12814
Y2H Prey Pooling
25416956
Intra
MICALL2 Q8IY33 ACTN1 Homo sapiens P12814
Y2H Prey Pooling
32296183
Intra
MICALL2 Q8IY33 ACTN1 Homo sapiens P12814
Validated Y2H
25416956
Intra
MICALL2 Q8IY33 ACTN2 Homo sapiens P35609
Y2H Array
31515488
Intra
MICALL2 Q8IY33 ACTN2 Homo sapiens P35609
Validated Y2H
25416956
Intra
MICALL2 Q8IY33 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
32296183
Intra
MICALL2 Q8IY33 ACTN2 Homo sapiens P35609
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Dermatomycosis

  • Dermatomycoses
Dyschromatosis Universalis Hereditaria

  • Duh
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08429 MICALL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22011 Micall2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MICALL2 VGNC VGNC:31460
Mus musculus MICALL2 MGD MGI:2444818
Macaca mulatta MICALL2 VGNC VGNC:74620
Canis familiaris MICALL2 VGNC VGNC:54329
Rattus norvegicus MICALL2 RGD RGD:1307875
Felis catus MICALL2 VGNC VGNC:80593
Others MICALL2 NCBI