INTS7 - integrator complex subunit 7 Gene

Also Known as INT7; C1orf73

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25896

About INTS7

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,940,403-212,035,557 (from NCBI)

This gene has 11 transcripts (splice variants) and 204 orthologues. Broad expression in testis (RPKM 9.9), lymph node (RPKM 3.5) and 24 other tissues.

Summary

This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

INTS7 Products (4)

mRNA Protein Name
NM_001199809.2 NP_001186738.1 integrator complex subunit 7 isoform 4
NM_001199811.2 NP_001186740.1 integrator complex subunit 7 isoform 2
NM_001199812.2 NP_001186741.1 integrator complex subunit 7 isoform 3
NM_015434.4 NP_056249.1 integrator complex subunit 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16239144 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
21659603 GOA
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
21659603 GOA
involved in snRNA processing IDA
IDA: Inferred from direct assay
16239144 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
21659603 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23904267 GOA
part of integrator complex IDA
IDA: Inferred from direct assay
16239144 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23904267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrator complex subunit 7

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06857 INTS7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus INTS7 RGD RGD:1308014
Felis catus INTS7 VGNC VGNC:62947
Macaca mulatta INTS7 VGNC VGNC:73644
Bos taurus INTS7 VGNC VGNC:30233
Canis familiaris INTS7 VGNC VGNC:42056
Mus musculus INTS7 MGD MGI:1924315