3113010-46-8
Chemical Structure
WRN-IN-24
- CAS No.: 3113010-46-8
- Formula:C24H28F3N5O6S2
- Molecular Weight:603.63
InChIKey: HWRFPRANIZSAOX-AUUUKSDWSA-N
SMILES: O=C(C1=C(OC2=CC=CC=C2)N=C(C(F)(F)C)N=C1NC3CN(S(=O)(C)=O)C3)N[C@@H](C4CC4)/C=C(F)/S(=O)(C)=O
Biological Activity: WRN-IN-24 is an orally active allosteric covalent Werner syndrome helicase (WRN) inhibitor with an IC50 of 201 nM. WRN-IN-24 binds to a novel allosteric cavity, forms an additional hydrogen bond with K894, and functionally inhibits WRN activity. WRN-IN-24 inhibits colorectal cancer cells proliferation and exerts dose-dependent antitumor activity in xenograft mouse models. WRN-IN-24 can be used for the research of microsatellite instability-high cancers, including colorectal cancer[1].
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WRN-IN-24 | WRN-IN-24 is an orally active allosteric covalent Werner syndrome helicase (WRN) inhibitor with an IC50 of 201 nM. WRN-IN-24 binds to a novel allosteric cavity, forms an additional hydrogen bond with K894, and functionally inhibits WRN activity. WRN-IN-24 inhibits colorectal cancer cells proliferation and exerts dose-dependent antitumor activity in xenograft mouse models. WRN-IN-24 can be used for the research of microsatellite instability-high cancers, including colorectal cancer. | |||||||||||||||||||||
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Keywords
