3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors

  • Bioorg Med Chem Lett. 2009 May 1;19(9):2464-7. doi: 10.1016/j.bmcl.2009.03.054.
An T Vu  1 ,  Stephen T Cohn ,  Eugene A Terefenko ,  William J Moore ,  Puwen Zhang ,  Paige E Mahaney ,  Eugene J Trybulski ,  Igor Goljer ,  Rebecca Dooley ,  Jenifer A Bray ,  Grace H Johnston ,  Jennifer Leiter ,  Darlene C Deecher
Affiliations
  • 1. Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
PMID: 19329313 DOI: 10.1016/j.bmcl.2009.03.054
Abstract

A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the Dopamine Transporter.