1191252-49-9
1191252-49-9
Chemical Structure
IOWH-032
- CAS. Nr.: 1191252-49-9
- Formula:C22H15Br2N3O4
- Molecular Weight:545.18
IUPAC Name: 3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide
InChIKey: DSFNLJXHXBIKDS-UHFFFAOYSA-N
SMILES: BrC1=C(O)C(Br)=CC(C2=NOC(C(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=O)=N2)=C1
Biological Activity: IOWH-032 is a a synthetic anti-secretory molecule, is a potent CFTR inhibitor with an IC50 value of 8 μM. IOWH-032 also is a anti-diarrheal agent[1][2].
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IOWH-032 | 99.63% | IOWH-032 is a a synthetic anti-secretory molecule, is a potent CFTR inhibitor with an IC50 value of 8 μM. IOWH-032 also is a anti-diarrheal agent. | ||||||||||||||||||||
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References
- [1]. Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation
- [2]. de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25. [Content Brief]
Keywords
