355400-87-2
Chemical Structure
Topoisomerase I/II inhibitor 8
- CAS. Nr.: 355400-87-2
- Formula:C14H11Br2NO5S2
- Molecular Weight:497.18
InChIKey: LMNXQDKRQCXSLB-YWEYNIOJSA-N
SMILES: O=C(CN1C(/C(SC1=S)=C/C2=CC(OCC)=C(C(Br)=C2Br)O)=O)O
Biological Activity: Topoisomerase I/II Inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II, capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer treatment[1].
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Topoisomerase I/II inhibitor 8 | Topoisomerase I/II Inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II, capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer treatment. | |||||||||||||||||||||
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Keywords
