81682-91-9
81682-91-9
Chemical Structure
HTS10307
- CAS. Nr.: 81682-91-9
- Formula:C14H8N2O2S
- Molecular Weight:268.29
InChIKey: QIJGSXWHQIOUEW-UHFFFAOYSA-N
SMILES: O=C(N1)C(C#N)=C(C2=CC=CO2)C=C1C3=CC=CS3
Biological Activity: HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease[1].
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HTS10307 | HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease. | |||||||||||||||||||||
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References
Keywords
