Tgfbr3 - transforming growth factor beta receptor 3 Gene

Also Known as betaglycan

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29610

About Tgfbr3

Primary_assembly 14: 2,489,397-2,663,341 forward strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 203 orthologues, 2 paralogues and is associated with 5 phenotypes. Biased expression in Adrenal (RPKM 475.), Lung (RPKM 174.) and 9 other tissues.

Summary

Enables several functions, including activin binding activity; growth factor binding activity; and heparin binding activity. Involved in several processes, including animal organ regeneration; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor complex assembly. Located in cytoplasm; extracellular matrix; and extracellular space. Is integral component of plasma membrane. Part of receptor complex. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr3 Products (1)

mRNA Protein Name
NM_017256.1 NP_058952.1 transforming growth factor beta receptor type 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables activin binding IDA
IDA: Inferred from direct assay
12385827 RGD
enables fibroblast growth factor binding IDA
IDA: Inferred from direct assay
1556106 RGD
enables heparin binding IDA
IDA: Inferred from direct assay
8106553 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7852346 RGD
enables transforming growth factor beta binding IDA
IDA: Inferred from direct assay
1657407 RGD
contributes to transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
7852346 RGD
enables transforming growth factor beta receptor activity, type III IDA
IDA: Inferred from direct assay
8106553 RGD
enables transforming growth factor beta receptor binding IDA
IDA: Inferred from direct assay
8106553 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
9699514 RGD
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
10746731 RGD
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8106553 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
12385827 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
12183510 RGD
involved in transforming growth factor beta receptor complex assembly IMP
IMP: Inferred from mutant phenotype
8106553 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
2592419 RGD
located in membrane IDA
IDA: Inferred from direct assay
8106553 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
7852346 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfbr3 Protein Structure

ZP

ZP: smart00241 (455 - 732)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 853 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta receptor type 3

  • TGF-beta receptor type 3

  • TGF-beta receptor type III

  • TGFR-3

  • transforming growth factor, beta receptor III

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14450 TGFBR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14451 Tgfbr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14452 Tgfbr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14453 TGFBR3L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174529 Human TGFBR3 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfbr3 NCBI NCBI:7049
Mus musculus Tgfbr3 NCBI NCBI:21814