CST4 - Cyss cystatin S Gene

Also Known as Cst4

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 296234

Summary

Enables cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including negative regulation of peptidase activity; response to chromate; and response to protozoan. Located in extracellular space and secretory granule. Orthologous to several human genes including CST5 (Cystatin D); CST4 (Cystatin S); and CST2 (cystatin SA). [provided by Alliance of Genome Resources, Apr 2022]

CST4 Products (1)

mRNA	Protein	Name
NM_198685.2	NP_941958.1	cystatin-S precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	7575236	RGD
enables protease binding	IDA IDA: Inferred from direct assay	9631169	RGD

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell development	IEP IEP: Inferred from expression pattern	1967932	RGD
involved in cell killing	IDA IDA: Inferred from direct assay	7749605	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8862019	RGD
involved in negative regulation of peptidase activity	IDA IDA: Inferred from direct assay	3263967	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	7878088	RGD
involved in response to chromate	IEP IEP: Inferred from expression pattern	8374010	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	1685882	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7686006	RGD
involved in response to protozoan	IEP IEP: Inferred from expression pattern	7778093	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	1471486	RGD
involved in salivary gland development	IEP IEP: Inferred from expression pattern	10075146	RGD

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	9823730	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	7778093	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cystatin-S	LM protein cystatin-1 protein LM

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03265	CST4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CST4	NCBI	NCBI:1472