Srebf2 - sterol regulatory element binding transcription factor 2 Gene

Also Known as SREBP2; SREBP-2; Srebf2_retired

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300095

Summary

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription, DNA-templated; response to lead ion; and spermatogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm; dendrite; and nucleus. Biomarker of kidney disease (multiple); lipid storage disease; obesity; and visual epilepsy. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Srebf2 Products (1)

mRNA Protein Name
NM_001033694.2 NP_001028866.2 sterol regulatory element-binding protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables chromatin binding IDA
IDA: Inferred from direct assay
19470373 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12446768 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19470373 RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12446768 RGD
involved in response to hormone IMP
IMP: Inferred from mutant phenotype
19470373 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
16705668 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
17709436 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11551527 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
16723505 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in dendrite IDA
IDA: Inferred from direct assay
19124072 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sterol regulatory element-binding protein 2

  • sterol regulatory element binding factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13758 SREBF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21946 Srebf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179526 Sino-C / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srebf2 NCBI NCBI:6721