OTUD4 - OTU deubiquitinase 4 Gene

Also Known as HIN1; DUBA6; HSHIN1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54726

About OTUD4

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:145,133,650-145,180,589 (from NCBI)

This gene has 10 transcripts (splice variants), 146 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 19.7), bone marrow (RPKM 11.0) and 25 other tissues.

Summary

Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

OTUD4 Products (4)

mRNA	Protein	Name
NM_001102653.1	NP_001096123.1	OTU domain-containing protein 4 isoform 3
NM_001366057.1	NP_001352986.1	OTU domain-containing protein 4 isoform 4
NM_001366058.1	NP_001352987.1	OTU domain-containing protein 4 isoform 5
NM_017493.7	NP_059963.1	OTU domain-containing protein 4 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables K63-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	29395066	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	23827681	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	25944111	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	25944111	GOA
involved in negative regulation of interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	29395066	GOA
involved in negative regulation of toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	29395066	GOA
involved in protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	36943869	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	29395066	GOA
involved in regulation of protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	25944111	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD4 Protein Structure

OTU

0
200
400
600
800
1000
1114 a.a.

Protein Preferred Names	Protein Names
OTU domain-containing protein 4	HIV-1 induced protein HIN-1

OTUD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	OTUD4	Q01804	STAT1	Homo sapiens	P42224	Validated Y2H	25416956
Intra	OTUD4	Q01804	VDR	Homo sapiens	P11473-2	Y2H Array	32296183
Intra	OTUD4	Q01804	VDR	Homo sapiens	P11473-2	Y2H Prey Pooling	32296183
Intra	OTUD4	Q01804	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	OTUD4	Q01804	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	OTUD4	Q01804	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	OTUD4	Q01804	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	32296183
Intra	OTUD4	Q01804	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	OTUD4	Q01804	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	OTUD4	Q01804	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	OTUD4	Q01804	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	OTUD4	Q01804	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	OTUD4	Q01804	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	OTUD4	Q01804	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

OTUD4 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P84460	OTUD4 Antibody (YA4157)	WB, FC, ELISA	Human, Rat
HY-P84460A	OTUD4 Antibody (YA4157)(PBS only)	WB, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Boucher-Neuhauser Syndrome	Ataxia-Hypogonadism-Choroidal Dystrophy Syndrome BNHS Spinocerebellar Ataxia, Hypogonadotropic Hypogonadism, And Chorioretinal Dystrophy Boucher-Neuhäuser Syndrome Chorioretinal Dystrophy, Spinocerebellar Ataxia, And Hypogonadotropic Hypogonadism Ataxia - Hypogonadism - Choroidal Dystrophy Chorioretinal Dystrophy, Spinocerebellar Ataxia And Hypogonadotropic Hypogonadism Bns Cerebellar Ataxia With Hypogonadism And Choroidal Dystrophy Syndrome Boucher Neuhauser Syndrome
Gordon Holmes Syndrome	Cerebellar Ataxia And Hypogonadotropic Hypogonadism Lhrh Deficiency And Ataxia Cerebellar Ataxia-Hypogonadism Syndrome GDHS Cahh Luteinizing Hormone-Releasing Hormone Deficiency With Ataxia Gordon-Holmes Syndrome Deficiency Of Luteinizing Hormone-Releasing Hormone With Ataxia Luteinizing Hormone-Releasing Hormone, Deficiency Of, With Ataxia Cerebellar Ataxia - Hypogonadism Luteinizing Hormone Releasing Hormone, Deficiency Of With Ataxia Ataxia, Cerebellar, And Hypogonadotropic Hypogonadism
Nivelon-Nivelon-Mabille Syndrome	Chondrodysplasia-Pseudohermaphroditism Syndrome NNMS Chondrodysplasia-Disorder Of Sex Development Syndrome Nivelon Nivelon Mabille Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 16	Autosomal Recessive Spinocerebellar Ataxia 16 SCAR16 Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 16 Spinocerebellar Ataxia, Autosomal Recessive, 16 Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
Spinocerebellar Ataxia, Autosomal Recessive 24	SCAR24 Autosomal Recessive Spinocerebellar Ataxia 24 Spinocerebellar Ataxia, Autosomal Recessive, 24 Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-161774	ST80	Inhibitor	/	Unkown
HY-RS09873	OTUD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20073	Otud4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OTUD4	VGNC	VGNC:75675
Mus musculus	OTUD4	MGD	MGI:1098801
Felis catus	OTUD4	VGNC	VGNC:64000
Rattus norvegicus	OTUD4	RGD	RGD:1305606
Bos taurus	OTUD4	VGNC	VGNC:32495
Canis familiaris	OTUD4	VGNC	VGNC:44186
Others	OTUD4	NCBI