Patritumab deruxtecan
Based on 1 publication(s) in Google Scholar
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity.
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- Reinheit: 99.08%
- CAS. Nr.: 2227102-46-5
- Molecular Weight:155238 (average)
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Speicherung:
-80°C, protect from light
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Patritumab deruxtecan
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Biologische Aktivität
Patritumab deruxtecan exhibits activity against breast cancer cells expressing HER3 mutations with and without HER2 overexpression[1].
Patritumab deruxtecan (0-100 nM) binds to the surface of all HER3-mutant and HER3WT MDA-MB-231 cells in a concentration-dependent manner, but does not bind to the surface of HER3EV cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 2227102-46-5
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Appearance Liquid
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Molecular Weight 155238 (average)
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Color Colorless to light yellow
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SMILES
[Patritumab deruxtecan]
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Synonyms
HER3-DXd; U3-1402
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Versand
Shipping with dry ice.
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Speicherung
-80°C, protect from light
Publications (1)
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Journal Impact Factor
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Most Recent
Reinheit & Dokumentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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