4 Results for "

MUC1-C

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "MUC1-C" in MCE Product Catalog:

12
12 Cited Publications
Art. -Nr.: HY-136453
CAS. Nr.: 1352914-52-3
Reinheit:  98.38%
Forschungsgebiete:  

Cancer

CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B perturbs association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells [1] .
2
2 Cited Publications
Art. -Nr.: HY-P1925A
CAS. Nr.: 1222186-26-6
Forschungsgebiete:  

Cancer

GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice [1] .
Art. -Nr.: HY-P1925B
Target:  

Mucin

Forschungsgebiete:  

Cancer

L-GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. L-GO-203 TFA is an anti-cancer peptide for targeting intracellular proteins [1].
Art. -Nr.: HY-136453A
CAS. Nr.: 1352914-53-4
Reinheit:  99.92%
Target:  

Mucin Drug Isomer

Forschungsgebiete:  

Cancer

CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation [1].