RNF31 - ring finger protein 31 Gene

Also Known as HOIP; Paul; ZIBRA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55072

About RNF31

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,146,875-24,160,655 (from NCBI)

This gene has 36 transcripts (splice variants), 1 gene allele, 261 orthologues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 17.0), testis (RPKM 12.6) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein Ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

RNF31 Products (2)

mRNA	Protein	Name
NM_001310332.2	NP_001297261.1	E3 ubiquitin-protein ligase RNF31 isoform 2
NM_017999.5	NP_060469.4	E3 ubiquitin-protein ligase RNF31 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	29892012	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	21455181	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	28481331	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	23453807	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17006537	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	20005846	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	19136968	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19136968	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19136968	GOA
involved in positive regulation of xenophagy	IDA IDA: Inferred from direct assay	28481331	GOA
involved in protein linear polyubiquitination	IDA IDA: Inferred from direct assay	21455173	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	12629548	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of LUBAC complex	IDA IDA: Inferred from direct assay	17006537	GOA
part of LUBAC complex	IPI IPI: Inferred from physical interaction	21455180	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF31 Protein Structure

PUB

IBR

0
200
400
600
800
1000
1072 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF31	HOIL-1-interacting protein

RNF31 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF31	Q96EP0	RBCK1	Homo sapiens	Q9BYM8	GMS	17006537
Intra	RNF31	Q96EP0	RBCK1	Homo sapiens	Q9BYM8	Anti Bait CoIP	21455180
Intra	RNF31	Q96EP0	RBCK1	Homo sapiens	Q9BYM8	Anti Tag CoIP	17006537
Intra	RNF31	Q96EP0	RBCK1	Homo sapiens	Q9BYM8	Anti Tag CoIP	21455180
Intra	RNF31	Q96EP0	RBCK1	Homo sapiens	Q9BYM8	Pull Down	17006537
Intra	RNF31	Q96EP0	SMAD3	Homo sapiens	P84022	Y2H	21988832
Intra	RNF31	Q96EP0	UBE2D2	Homo sapiens	P62837	Solution Sedimentation	26789245
Intra	RNF31	Q96EP0	UBE2D2	Homo sapiens	P62837	X-Ray Diffraction	26789245
Intra	RNF31	Q96EP0	UBE2D2	Homo sapiens	P62837	GMS	26789245
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Anti Tag CoIP	24141947
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Y2H	22158122
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Anti Tag CoIP	21455181
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Pull Down	21455180
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Anti Bait CoIP	21455180
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Anti Tag CoIP	33961781
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Anti Tag CoIP	21455180
Intra	RNF31	Q96EP0	SHARPIN	Homo sapiens	Q9H0F6	Anti Tag CoIP	28514442
Intra	RNF31	Q96EP0	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	RNF31	Q96EP0	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	RNF31	Q96EP0	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	RNF31	Q96EP0	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	21455180
Intra	RNF31	Q96EP0	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency	PGBM1 Polyglucosan Body Myopathy Type 1 Polyglucosan Body Myopathy, Early-Onset, With Or Without Immunodeficiency Pbmei Autoinflammatory Syndrome With Pyogenic Bacterial Infection And Amylopectinosis Polyglucosan Body Myopathy 1 Without Immunodeficiency Polyglucosan Body Myopathy, Early-Onset, With/Without Immunodeficiency
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Otulipenia Otulin-Related Autoinflammatory Syndrome AIPDS Oras Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome Autoinflammation, Panniculitis And Dermatosis Syndrome Otulin Deficiency
Incontinentia Pigmenti	Bloch-Sulzberger Syndrome IP Incontinentia Pigmenti, Familial Male-Lethal Type Incontinentia Pigmenti Syndrome Bloch-Siemens Syndrome Ip2 Incontinentia Pigmenti, Type Ii, Formerly Ip2, Formerly Incontinentia Pigmenti Type 2 Bloch-Siemens-Sulzberger Syndrome Familial Incontinentia Pigmenti Male-Lethal Type Familial Incontinentia Pigmenti Type Ii Incontinentia Pigmenti, Type Ii Bloch Sulzberger Syndrome Incontinentia Pigmenti Achromians Incontinentia Pigmenti Of Bloch-Sulzberger Nevus Pigmentosus Systematicus
Glycogen Storage Disease Iv	Gsd Iv Glycogen Branching Enzyme Deficiency Andersen Disease Amylopectinosis Glycogen Storage Disease Type Iv GSD4 Brancher Deficiency Glycogen Storage Disease, Type Iv Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gbe1 Deficiency Glycogenosis Iv Cirrhosis, Familial, With Deposition Of Abnormal Glycogen Glycogen Storage Disease Type 4 Glycogenosis 4 Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features Andersen'S Disease Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Brancher Deficiency Glycogenosis Branching-Transferase Deficiency Glycogenosis Deficiency Of 1,4-Alpha-Glucan Branching Enzyme Andersen-Tawil Syndrome Gsd 4 Andersen Cardiodysrhythmic Periodic Paralysis Lqt7 Long Qt Syndrome 7 Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type Andersen Glycogenosis Branching Enzyme Deficiency Glycogenosis, Type Iv Gsd Type Iv Type Iv Glycogenosis Gbe Deficiency, Childhood Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Gsd Type 4, Childhood Neuromuscular Form Gsdiv, Childhood Neuromuscular Form Glycogen Storage Disease Type 4, Childhood Neuromuscular Form Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogenosis Type 4, Childhood Neuromuscular Form Glycogenosis Type Iv, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gbe Deficiency, Adult Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gsd Type 4, Adult Neuromuscular Form Gsdiv, Adult Neuromuscular Form Glycogen Storage Disease Type 4, Adult Neuromuscular Form Glycogen Storage Disease Type Iv, Adult Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Glycogenosis Type 4, Adult Neuromuscular Form Glycogenosis Type Iv, Adult Neuromuscular Form Gbe Deficiency, Congenital Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gsd Type 4, Congenital Neuromuscular Form Gsdiv, Congenital Neuromuscular Form Glycogen Storage Disease Type 4, Congenital Neuromuscular Form Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Glycogenosis Type 4, Congenital Neuromuscular Form Glycogenosis Type Iv, Congenital Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Type 4, Childhood Combined Hepatic And Myopathic Form Gsdiv, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Fatal Perinatal Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Gsd Type 4, Fatal Perinatal Neuromuscular Form Gsdiv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gbe Deficiency, Non Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gsd Type 4, Non Progressive Hepatic Form Gsdiv, Non Progressive Hepatic Form Glycogen Storage Disease Type 4, Non Progressive Hepatic Form Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Glycogenosis Type 4, Non Progressive Hepatic Form Glycogenosis Type Iv, Non Progressive Hepatic Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gbe Deficiency, Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gsd Type 4, Progressive Hepatic Form Gsdiv, Progressive Hepatic Form Glycogen Storage Disease Type 4, Progressive Hepatic Form Glycogen Storage Disease Type Iv, Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Glycogenosis Type 4, Progressive Hepatic Form Glycogenosis Type Iv, Progressive Hepatic Form Glycogen Storage Disease 4 Gsd-Iv Storage Disease, Glycogen, Type Iv
Clear Cell Adenoma
Immunodeficiency 57 With Autoinflammation	Immunodeficiency 57 IMD57 Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections-Lymphopenia Syndrome
Immunodeficiency 11	Immunodeficiency 11a Severe Combined Immunodeficiency Due To Card11 Deficiency IMD11A Imd11 Card11 Immunodeficiency Scid Due To Card11 Deficiency Card11 Deficiency Immunodeficiency 11 A
Hepatic Venoocclusive Disease With Immunodeficiency	VODI Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome Hepatic Veno-Occlusive Disease With Immunodeficiency Familial Veno-Occlusive Disease With Immunodeficiency Veno-Occlusive Disease And Immunodeficiency Syndrome Vodi Syndrome Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2478	Taraxasteryl acetate	Inducer	98.74%	Unkown
HY-RS12086	RNF31 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21036	Rnf31 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27553	Rnf31 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF31	RGD	RGD:1305513
Mus musculus	RNF31	MGD	MGI:1934704
Felis catus	RNF31	VGNC	VGNC:104712
Others	RNF31	NCBI