DSE - dermatan sulfate epimerase Gene

Also Known as DSEP; DSEPI; SART2; EDSMC2; SART-2; DS-epi1

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 29940

Summary

The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in Cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]

DSE Products (1)

mRNA Protein Name
NM_001322941.2 NP_001309870.1 dermatan-sulfate epimerase isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chondroitin-glucuronate 5-epimerase activity IDA
IDA: Inferred from direct assay
16505484 GOA
Biological Process GO Annotation Evidence References Source
involved in dermatan sulfate biosynthetic process IDA
IDA: Inferred from direct assay
16505484 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10679095 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10679095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dermatan-sulfate epimerase

  • DS epimerase

  • chondroitin-glucuronate 5-epimerase

  • squamous cell carcinoma antigen recognized by T-cells 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183055 DSG-PEG1000-SH / Unkown
HY-183055A DSG-PEG2000-SH / Unkown
HY-183055B DSG-PEG3400-SH / Unkown
HY-183055C DSG-PEG5000-SH / Unkown
HY-183055D DSG-PEG10000-SH / Unkown
HY-RS16411 DSE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21282 Dse Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27801 Dse Rat Pre-designed siRNA Set A Pre-designed Set / Unkown