DSG-PEG5000-SH
DSE-PEG5000-SH (DSE-PEG5000-Thiol) is a conjugate composed of DSE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DSE-PEG5000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.
For research use only. We do not sell to patients.
- Molecular Weight:5000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
The structure of DSE-PEG-SH comprises three key components that work synergistically:
DSE: Acts as a hydrophobic anchor, responsible for securely embedding the entire molecule into the membrane structure of lipid nanoparticles.
PEG chain: Acts as a hydrophilic spacer arm, forming a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.
Thiol group (-SH): Located at the end of the PEG chain, it can undergo a specific thiol-maleimide addition reaction with maleimide groups, and can also achieve reversible cross-linking through disulfide bond formation (-S-S-). Thiol groups can also form stable Au-S bonds with the surface of gold nanoparticles, enabling the construction of liposome-gold nanoparticle composite systems.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 5000 (Average)
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SMILES
CCCCCCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCCCCCC)=O)COCCOCCS)=O.[n]
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Synonyms
DSG-PEG5000-Thiol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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