SINHCAF - SIN3-HDAC complex associated factor Gene

Also Known as L4; TERA; FAM60A; C12orf14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58516

About SINHCAF

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:31,280,584-31,326,150 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 270 orthologues. Ubiquitous expression in endometrium (RPKM 24.9), lymph node (RPKM 18.1) and 25 other tissues.

Summary

Involved in negative regulation of cell migration. Part of Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]

SINHCAF Products (3)

mRNA Protein Name
NM_001135811.2 NP_001129283.1 SIN3-HDAC complex-associated factor
NM_001135812.2 NP_001129284.1 SIN3-HDAC complex-associated factor
NM_021238.3 NP_067061.1 SIN3-HDAC complex-associated factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23752268 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
22984288 GOA
Cellular Component GO Annotation Evidence References Source
part of Sin3-type complex IDA
IDA: Inferred from direct assay
22984288 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SINHCAF Protein Structure

FAM60A

FAM60A: Protein Family FAM60A (2 - 199)

  • 0
  • 100
  • 200
  • 221 a.a.
Protein Preferred Names Protein Names

SIN3-HDAC complex-associated factor

  • family with sequence similarity 60 member A

SINHCAF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SINHCAF Q9NP50 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
33961781
Intra
SINHCAF Q9NP50 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
28514442
Intra
SINHCAF Q9NP50 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
23752268
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SINHCAF Proteins

Cat. No. Product Name Accession Purity
HY-P700391 SINHCAF Protein, Human (GST) Q9NP50-1 (M1-W221) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12927 SINHCAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20643 Sinhcaf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27153 Sinhcaf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SINHCAF RGD RGD:1595037
Macaca mulatta SINHCAF VGNC VGNC:103865
Canis familiaris SINHCAF VGNC VGNC:49879
Bos taurus SINHCAF VGNC VGNC:34626
Mus musculus SINHCAF MGD MGI:1929091
Others SINHCAF NCBI