Arpc2 - actin related protein 2/3 complex, subunit 2 Gene

Also Known as 34kDa; p34-Arc; 2210023N03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76709

About Arpc2

Chromosome 1: 74,275,243-74,307,368 forward strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 240 orthologues and is associated with 13 phenotypes. Ubiquitous expression in placenta adult (RPKM 131.5), bladder adult (RPKM 118.3) and 28 other tissues.

Summary

Predicted to enable ATPase binding activity; actin filament binding activity; and glutamate receptor binding activity. Predicted to be a structural constituent of Cytoskeleton. Acts upstream of or within positive regulation of actin filament polymerization and positive regulation of substrate adhesion-dependent cell spreading. Located in several cellular components, including focal adhesion; glutamatergic synapse; and muscle cell projection membrane. Is expressed in lens pit. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Arpc2 Products (2)

mRNA Protein Name
NM_029711.2 NP_083987.1 actin-related protein 2月3日 complex subunit 2
NM_001357387.1 NP_001344316.1 actin-related protein 2月3日 complex subunit 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18836449 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
18836449 MGI
acts upstream of or within positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
22689987 MGI
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
18836449 MGI
located in endosome IDA
IDA: Inferred from direct assay
22689987 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
12473693 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
24413018 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24413018 MGI
located in muscle cell projection membrane IDA
IDA: Inferred from direct assay
22553210 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22689987 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
34269176 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
34269176 MGI
is active in synapse EXP
EXP: Inferred from Experiment
24413018 MGI
is active in synapse IDA
IDA: Inferred from direct assay
24413018 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
34269176 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Arpc2 Protein Structure

P34-Arc

P34-Arc: pfam04045 (56 - 283)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

actin-related protein 2/3 complex subunit 2

  • arp2/3 complex 34 kDa subunit

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114657A Benproperine phosphate Inhibitor 99.93% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01015 ARPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01016 Arpc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01017 Arpc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arpc2 NCBI NCBI:10109