2387678-02-4
Chemical Structure
TGFβ-IN-2
- CAS No.: 2387678-02-4
- Formula:C22H22N2O4
- Molecular Weight:378.42
IUPAC Name: (E)-N-(2-(dimethylamino)ethyl)-3-(1H-indol-3-yl)-N-(pyridin-2-yl)acrylamide
InChIKey: PHLACHIKRYAJCZ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)OC2=CC(OC3=CC=CC=C32)=O)CN4CCCCC4
Biological Activity: TGFβ-IN-2 is an orally active TGF-β inhibitor. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin (HY-108345)-induced pulmonary fibrosis model. TGFβ-IN-2 can be used for the study of pulmonary fibrosis[1].
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TGFβ-IN-2 | 99.37% | TGFβ-IN-2 is an orally active TGF-β inhibitor. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin (HY-108345)-induced pulmonary fibrosis model. TGFβ-IN-2 can be used for the study of pulmonary fibrosis. | ||||||||||||||||||||
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Keywords
