81957-76-8
Chemical Structure
Mianserin-d3
Synonym(s): Mianserine-d3
- CAS No.: 81957-76-8
- Formula:C18H17D3N2
- Molecular Weight:267.38
IUPAC Name: 5-(methyl-d3)pyrimidine-2,4(1H,3H)-dione
InChIKey: UEQUQVLFIPOEMF-FIBGUPNXSA-N
SMILES: [2H]C([2H])([2H])N1CC2N(CC1)C3=CC=CC=C3CC4=CC=CC=C42
Biological Activity: Mianserin-d3 is the deuterium labeled Mianserin (HY-B0188). Mianserin (Mianserine) is an orally active H1 receptor antagonist. Mianserin can activate κ-opioid receptor and octopamine receptor. Mianserin increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A (HY-P1333)-induced MAPK phosphorylation. Mianserin modulates social and exploratory behaviour, raises electroconvulsive thresholds. Mianserin can be used for the research of neurological disease, such as depression and epilepsy[1][2][3][4][5].
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Mianserin-d3 | Mianserin-d3 is the deuterium labeled Mianserin (HY-B0188). Mianserin (Mianserine) is an orally active H1 receptor antagonist. Mianserin can activate κ-opioid receptor and octopamine receptor. Mianserin increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A (HY-P1333)-induced MAPK phosphorylation. Mianserin modulates social and exploratory behaviour, raises electroconvulsive thresholds. Mianserin can be used for the research of neurological disease, such as depression and epilepsy. | |||||||||||||||||||||
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Mianserin | 99.42% | Mianserin (Mianserine) is an orally active H1 receptor antagonist. Mianserin can activate κ-opioid receptor and octopamine receptor. Mianserin increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A (HY-P1333)-induced MAPK phosphorylation. Mianserin modulates social and exploratory behaviour, raises electroconvulsive thresholds. Mianserin can be used for the research of neurological disease, such as depression and epilepsy. | ||||||||||||||||||||
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- [1]. Olianas MC, et al. The atypical antidepressant Mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012;167(6):1329-1341. [Content Brief]
- [2]. Gao B, et al. Effects of acute and chronic administration of the antidepressants, imipramine, phenelzine and Mianserin, on the social behaviour of mice. Neuropharmacology. 1994;33(6):813-824. [Content Brief]
- [3]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27;191(2):221-4. [Content Brief]
- [4]. Borowicz KK, et al. Acute and chronic treatment with Mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model. Psychopharmacology (Berl). 2007;195(2):167-174. [Content Brief]
- [5]. Nowak J Z, Arrang J M, Schwartz J C, et al. Interaction between Mianserin, an antidepressant drug, and central H1-and H2-histamine-receptors: in vitro and in vivo studies and radioreceptor assay[J]. Neuropharmacology, 1983, 22(3): 259-266.
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