1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Mianserin

Mianserin (Synonyms: Mianserine)

Cat. No.: HY-B0188
Handling Instructions

Mianserin is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

For research use only. We do not sell to patients.

Mianserin Chemical Structure

Mianserin Chemical Structure

CAS No. : 24219-97-4

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Description

Mianserin is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant. Target: H1 receptor Mianserin is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects. It is not approved for use in the US, but its analogue, mirtazapine, is. Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose. Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, and α2-adrenergic receptors, and also inhibits the reuptake of norepinephrine. As a high affinity H1 receptor inverse agonist, mianserin has strong antihistamine effects (sedation, weight gain, etc.). Contrarily, it has negligible affinity for the mACh receptors, and thus lacks any anticholinergic properties. It was recently found to be a potent kappa opioid receptor agonist. In addition, mianserin also appears to be a potent antagonist of the neuronal octopamine receptor. What implications this may have on mood are currently unknown, however octopamine has been implicated in the regulation of sleep, appetite and insulin production and therefore may theoretically contribute to the overall side effect profile of mianserin.

Clinical Trial
Molecular Weight

264.36

Formula

C18H20N2

CAS No.
SMILES

CN(CC1)CC2N1C3=CC=CC=C3CC4=CC=CC=C24

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Please store the product under the recommended conditions in the Certificate of Analysis.

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