SRRM1 - serine and arginine repetitive matrix 1 Gene

Also Known as 160-KD; POP101; SRM160

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10250

About SRRM1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,643,302-24,673,281 (from NCBI)

This gene has 26 transcripts (splice variants) and 156 orthologues. Ubiquitous expression in ovary (RPKM 22.6), prostate (RPKM 22.3) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nuclear speck. Part of catalytic step 2 spliceosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Apr 2022]

SRRM1 Products (35)

mRNA Protein Name
NM_001303448.2 NP_001290377.1 serine/arginine repetitive matrix protein 1 isoform 1
NM_001303449.1 NP_001290378.1 serine/arginine repetitive matrix protein 1 isoform 3
NM_001366565.1 NP_001353494.1 serine/arginine repetitive matrix protein 1 isoform 4
NM_001366566.1 NP_001353495.1 serine/arginine repetitive matrix protein 1 isoform 4
NM_001366567.1 NP_001353496.1 serine/arginine repetitive matrix protein 1 isoform 5
NM_001366568.1 NP_001353497.1 serine/arginine repetitive matrix protein 1 isoform 6
NM_001366569.1 NP_001353498.1 serine/arginine repetitive matrix protein 1 isoform 7
NM_001366570.1 NP_001353499.1 serine/arginine repetitive matrix protein 1 isoform 8
NM_001366571.1 NP_001353500.1 serine/arginine repetitive matrix protein 1 isoform 6
NM_001366572.1 NP_001353501.1 serine/arginine repetitive matrix protein 1 isoform 9
NM_001366573.1 NP_001353502.1 serine/arginine repetitive matrix protein 1 isoform 10
NM_001366575.1 NP_001353504.1 serine/arginine repetitive matrix protein 1 isoform 11
NM_001366576.1 NP_001353505.1 serine/arginine repetitive matrix protein 1 isoform 12
NM_001366577.1 NP_001353506.1 serine/arginine repetitive matrix protein 1 isoform 13
NM_001366578.1 NP_001353507.1 serine/arginine repetitive matrix protein 1 isoform 14
NM_001366581.1 NP_001353510.1 serine/arginine repetitive matrix protein 1 isoform 15
NM_001366582.1 NP_001353511.1 serine/arginine repetitive matrix protein 1 isoform 16
NM_001366584.1 NP_001353513.1 serine/arginine repetitive matrix protein 1 isoform 5
NM_001366585.1 NP_001353514.1 serine/arginine repetitive matrix protein 1 isoform 18
NM_001366586.1 NP_001353515.1 serine/arginine repetitive matrix protein 1 isoform 19
NM_001366587.1 NP_001353516.1 serine/arginine repetitive matrix protein 1 isoform 20
NM_001366588.1 NP_001353517.1 serine/arginine repetitive matrix protein 1 isoform 21
NM_001366589.1 NP_001353518.1 serine/arginine repetitive matrix protein 1 isoform 22
NM_001366590.1 NP_001353519.1 serine/arginine repetitive matrix protein 1 isoform 10
NM_001366591.1 NP_001353520.1 serine/arginine repetitive matrix protein 1 isoform 20
NM_001366592.1 NP_001353521.1 serine/arginine repetitive matrix protein 1 isoform 23
NM_001366593.1 NP_001353522.1 serine/arginine repetitive matrix protein 1 isoform 18
NM_001366594.1 NP_001353523.1 serine/arginine repetitive matrix protein 1 isoform 14
NM_001366595.1 NP_001353524.1 serine/arginine repetitive matrix protein 1 isoform 24
NM_001366596.1 NP_001353525.1 serine/arginine repetitive matrix protein 1 isoform 25
NM_001366597.1 NP_001353526.1 serine/arginine repetitive matrix protein 1 isoform 26
NM_001366598.1 NP_001353527.1 serine/arginine repetitive matrix protein 1 isoform 9
NM_001366599.1 NP_001353528.1 serine/arginine repetitive matrix protein 1 isoform 5
NM_001366600.1 NP_001353529.1 serine/arginine repetitive matrix protein 1 isoform 6
NM_005839.4 NP_005830.2 serine/arginine repetitive matrix protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23602568 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRRM1 Protein Structure

PWI

PWI: PWI domain (45 - 116)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 904 a.a.
Protein Preferred Names Protein Names

serine/arginine repetitive matrix protein 1

  • SR-related nuclear matrix protein of 160 kDa

SRRM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRRM1 Q8IYB3 CLK2 Homo sapiens P49760-3
Validated Y2H
26871637
Intra
SRRM1 Q8IYB3 CLK2 Homo sapiens P49760-3
Y2H Array
26871637
Intra
SRRM1 Q8IYB3 CLK2 Homo sapiens P49760-3
Y2H Prey Pooling
26871637
Intra
SRRM1 Q8IYB3 SRRM4 Homo sapiens A7MD48
Y2H Array
32296183
Intra
SRRM1 Q8IYB3 SRRM4 Homo sapiens A7MD48
Y2H Prey Pooling
32296183
Intra
SRRM1 Q8IYB3 CLK2 Homo sapiens P49760
Y2H Prey Pooling
26871637
Intra
SRRM1 Q8IYB3 CLK2 Homo sapiens P49760
Y2H Prey Pooling
25416956
Intra
SRRM1 Q8IYB3 CLK2 Homo sapiens P49760
Validated Y2H
26871637
Intra
SRRM1 Q8IYB3 CLK2 Homo sapiens P49760
Y2H Array
26871637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139499 Sudemycin D6 Modulator / Unkown
HY-RS13786 SRRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21768 Srrm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28285 Srrm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRRM1 RGD RGD:1311258
Mus musculus SRRM1 MGD MGI:1858303
Bos taurus SRRM1 VGNC VGNC:35294
Macaca mulatta SRRM1 VGNC VGNC:100149
Felis catus SRRM1 VGNC VGNC:107640
Others SRRM1 NCBI