Sudemycin D6
Sudemycin D6 is a pre-mRNA splicing modulator with potent antitumour activity. Sudemycin D6 changes splice site usage of the DUSP11 and SRRM1 pre-mRNA. Sudemycin D6 reduces survival and alters cell cycle in haematopoietic cells expressing mutant U2AF1. Sudemycin D6 attenuates mutant U2AF1-induced haematopoietic progenitor cell expansion in U2AF1(S34F) transgenic mice. Sudemycin D6 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1510837-67-8
- Formula: C27H42N2O5
- Molecular Weight:474.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
50 nM
Compound: 3, sudemycin D6
|
Cytotoxicity against human HeLa cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HeLa cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| JeKo-1 | IC50 |
22 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| PC-3 | IC50 |
142 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human PC3 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human PC3 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| SK-MEL-2 | IC50 |
39 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human SK-MEL-2 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| SK-N-AS | IC50 |
81 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human SK-N-AS cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human SK-N-AS cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
Chemical Information
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CAS No. 1510837-67-8
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Molecular Weight 474.63
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Formula C27H42N2O5
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SMILES
CNC(O[C@@H](C)/C=C\C(N[C@@H](CC1)CC[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(CC(C)(O2)C)CO3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shirai CL, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017 Jan 9;8:14060. [Content Brief]
[2]. Thurman M, et al. Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6. Biomark Insights. 2017 Sep 12;12:1177271917730557. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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