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Nfib - nuclear factor I/B Gene

Also Known as CTF; NF1-B; NFI-B; NF-I/B; 6720429L07Rik; E030026I10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18028

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including lung epithelial cell differentiation; negative regulation of cell population proliferation; and nervous system development. Acts upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and response to bacterium. Located in cerebellar mossy fiber and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and respiratory system. Orthologous to human NFIB (nuclear factor I B). [provided by Alliance of Genome Resources, Apr 2022]

Nfib Products (5)

mRNA	Protein	Name
NM_001113209.2	NP_001106680.1	nuclear factor 1 B-type isoform 1
NM_001113210.2	NP_001106681.1	nuclear factor 1 B-type isoform 2
NM_001286127.1	NP_001273056.1	nuclear factor 1 B-type isoform 4
NM_001286131.1	NP_001273060.1	nuclear factor 1 B-type isoform 5
NM_008687.6	NP_032713.3	nuclear factor 1 B-type isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21513708	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17904922	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29106906	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in anterior commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	19961580	MGI
acts upstream of or within cell differentiation involved in salivary gland development	IMP IMP: Inferred from mutant phenotype	25403566	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15632069	MGI
involved in cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	27965439	MGI
acts upstream of or within cell quiescence	IMP IMP: Inferred from mutant phenotype	33004674	MGI
involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17904922	MGI
involved in club cell differentiation	IMP IMP: Inferred from mutant phenotype	21513708	MGI
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	19961580	MGI
acts upstream of or within exit from mitosis	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15632069	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	29106906	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	31128945	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	29106906	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	33004674	MGI
acts upstream of or within glandular epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	25403566	MGI
involved in glial cell differentiation	IMP IMP: Inferred from mutant phenotype	19961580	MGI
acts upstream of or within glial cell fate specification	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within glial cell proliferation	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	15632069	MGI
involved in lung ciliated cell differentiation	IMP IMP: Inferred from mutant phenotype	21513708	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	11850179	MGI
involved in negative regulation of epithelial cell proliferation involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	21513708	MGI
involved in negative regulation of mesenchymal cell proliferation involved in lung development	IMP IMP: Inferred from mutant phenotype	21513708	MGI
acts upstream of or within negative regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15632069	MGI
acts upstream of or within neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9056636	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19706729	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17904922	MGI
involved in principal sensory nucleus of trigeminal nerve development	IMP IMP: Inferred from mutant phenotype	19107796	MGI
acts upstream of or within regeneration	IMP IMP: Inferred from mutant phenotype	32393888	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	33004674	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	31128945	MGI
acts upstream of or within salivary gland cavitation	IMP IMP: Inferred from mutant phenotype	25403566	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	32393888	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15632069	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	32393888	MGI
involved in type I pneumocyte differentiation	IMP IMP: Inferred from mutant phenotype	21513708	MGI
involved in type II pneumocyte differentiation	IMP IMP: Inferred from mutant phenotype	21513708	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cerebellar mossy fiber	IDA IDA: Inferred from direct assay	19107796	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21513708	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear factor 1 B-type	CCAAT-box-binding transcription factor TGGCA-binding protein nuclear factor 1/B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09250	NFIB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfib	NCBI	NCBI:4781