NFIB - nuclear factor I B Gene

Homo sapiens

Also known as CTF; MACID; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB

Gene ID: 4781 | Gene type: protein coding

About NFIB

Cytogenetic location: 9p23-p22.3 Genomic coordinates (GRCh38): 9:14,081,843-14,532,077 (from NCBI)

This gene has 22 transcripts (splice variants), 213 orthologues, 3 paralogues and is associated with 78 phenotypes. Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development; negative regulation of DNA binding activity; and regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NFIB Products(28)

mRNA	Protein	Name
NM_001190737.2	NP_001177666.1	nuclear factor 1 B-type isoform 1
NM_001190738.2	NP_001177667.1	nuclear factor 1 B-type isoform 2
NM_001282787.2	NP_001269716.1	nuclear factor 1 B-type isoform 4
NM_001369458.1	NP_001356387.1	nuclear factor 1 B-type isoform 5
NM_001369459.1	NP_001356388.1	nuclear factor 1 B-type isoform 6
NM_001369460.1	NP_001356389.1	nuclear factor 1 B-type isoform 7
NM_001369461.1	NP_001356390.1	nuclear factor 1 B-type isoform 8
NM_001369462.1	NP_001356391.1	nuclear factor 1 B-type isoform 9
NM_001369463.1	NP_001356392.1	nuclear factor 1 B-type isoform 10
NM_001369464.1	NP_001356393.1	nuclear factor 1 B-type isoform 11
NM_001369465.1	NP_001356394.1	nuclear factor 1 B-type isoform 12
NM_001369466.1	NP_001356395.1	nuclear factor 1 B-type isoform 13
NM_001369467.1	NP_001356396.1	nuclear factor 1 B-type isoform 14
NM_001369468.1	NP_001356397.1	nuclear factor 1 B-type isoform 15
NM_001369469.1	NP_001356398.1	nuclear factor 1 B-type isoform 16
NM_001369470.1	NP_001356399.1	nuclear factor 1 B-type isoform 17
NM_001369471.1	NP_001356400.1	nuclear factor 1 B-type isoform 18
NM_001369472.1	NP_001356401.1	nuclear factor 1 B-type isoform 19
NM_001369473.1	NP_001356402.1	nuclear factor 1 B-type isoform 20
NM_001369474.1	NP_001356403.1	nuclear factor 1 B-type isoform 21
NM_001369475.1	NP_001356404.1	nuclear factor 1 B-type isoform 22
NM_001369476.1	NP_001356405.1	nuclear factor 1 B-type isoform 23
NM_001369477.1	NP_001356406.1	nuclear factor 1 B-type isoform 24
NM_001369478.1	NP_001356407.1	nuclear factor 1 B-type isoform 25
NM_001369479.1	NP_001356408.1	nuclear factor 1 B-type isoform 26
NM_001369480.1	NP_001356409.1	nuclear factor 1 B-type isoform 27
NM_001369481.1	NP_001356410.1	nuclear factor 1 B-type isoform 28
NM_005596.3	NP_005587.2	nuclear factor 1 B-type isoform 3

NFIB Protein Structure

NfI_DNAbd_pre-N

MH1

CTF_NFI

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

nuclear factor 1 B-type

CCAAT-box-binding transcription factor

Related Diseases

Diseases

Alias

Macrocephaly, Acquired, With Impaired Intellectual Development

MACID

Macrocephaly, Acquired, With Mental Retardation

Adenoid Cystic Carcinoma

Adenocystic Carcinoma	Cribriform Carcinoma
Cylindroma	Carcinoma Adenoid Cystic
Carcinoma, Adenoid Cystic	Adenoid Cystic Carcinoma Of Salivary Gland
Eccrine Dermal Cylindroma	Carcinoma, Cribriform

Breast Adenoid Cystic Carcinoma

Adenoid Cystic Breast Carcinoma	Adenoid Cystic Carcinoma Of Breast
Mammary Adenocystic Carcinoma

Lung Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lung

Pulmonary Adenoid Cystic Carcinoma

Sublingual Gland Adenoid Cystic Carcinoma

Sublingual Gland Cancer

Malignant Tumor Of Sublingual Gland

Malignant Tumor Of The Sublingual Gland

Synchronous Bilateral Breast Carcinoma

Tonsil Cancer

Tonsillar Neoplasms	Malignant Neoplasm Of Faucial Tonsil
Malignant Neoplasm Of Palatine Tonsil	Malignant Neoplasm Of Tonsil, Faucial
Malignant Tonsillar Tumor	Malignant Tumor Of Tonsil
Tonsillar Carcinoma	Malignant Neoplasm Tonsil

Oropharynx Cancer

Oropharyngeal Cancer	Oropharyngeal Carcinoma
Malignant Neoplasm Of Oropharynx	Malignant Oropharyngeal Tumor
Malignant Tumor Of Oropharynx	Malignant Tumour Of Mesopharynx
Oropharyngeal Cancer, Adult	Cancer Of The Oropharynx

Salivary Gland Carcinoma

Salivary Gland Cancer	Malignant Neoplasm Of Salivary Gland
Salivary Gland Neoplasms

Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome	Nfia-Related Disorder
Chromosome 1, Monosomy 1p32	BRMUTD
1p31p32 Microdeletion Syndrome	Nfia Haploinsufficiency
Del(1)(P31p32)	Monosomy 1p31p32
Nfia-Related Disorders

Salivary Gland Adenoid Cystic Carcinoma

Cylindroma

Infiltrating Lipoma

Intramuscular Lipoma

Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma	Adenomyo-Epithelioma
Clear Cell Carcinoma	Emc
Epithelial Myoepithelial Carcinoma	Glycogen-Rich Adenocarcinoma
Glycogen-Rich Adenoma	Monomorphic Clear Cell Tumor
Tubular Solid Adenoma	Adenocarcinoma, Clear Cell

Lacrimal Gland Carcinoma

Lacrimal Gland Cancer	Carcinoma Of The Lacrimal Gland
Malignant Neoplasm Of Lacrimal Gland	Malignant Tumour Of Lacrimal Gland
Neoplasm Of Lacrimal Gland	Tumor Of The Lacrimal Gland
Malignant Tumor Of Lacrimal Gland

Bartholin'S Gland Adenoid Cystic Carcinoma

Bartholin Gland Adenoid Cystic Carcinoma

Cervical Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of The Cervix Uteri

Spiradenoma

Eccrine Spiradenoma	Benign Eccrine Spiradenoma
Eccrine Spiradenoma Of Skin	Es
Eccrine Spiradenoma, Benign

Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma

Marshall-Smith Syndrome

MRSHSS	Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome
Mss

Lipoma Of Colon

Colonic Lipoma

Colon Lipoma

Large Intestine Lipoma

Lipoma Of Large Intestine

Colorectal Lipoma

Mammary Analogue Secretory Carcinoma

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Microglandular Adenosis

Breast Fibrocystic Disease	Adenosis - Breast
Adenosis Of The Breast	Fibrocystic Breast Disease
Breast Adenosis	Adenosis Of Breast

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Breast Secretory Carcinoma

Secretory Breast Carcinoma	Juvenile Breast Carcinoma
Juvenile Carcinoma Of The Breast	Juvenile Secretory Carcinoma Of Breast
Juvenile Breast Cancer	Sbc
Secretory Carcinoma Of The Breast

Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome	Spiegler-Brooke Syndrome
Familial Cylindromatosis	BRSS
Bss	Sbs
Multiple Familial Trichoepithelioma	Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma	Trichoepithelioma
Fc	Mft
Multiple Familial Trichoepitheliomas	Ccs
Turban Tumor Syndrome	Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma	Familial Multiple Trichoepitheliomata

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Cribriform Carcinoma

Ductal Carcinoma, Cribriform Type	Carcinoma Cribriform
Carcinoma, Cribriform

Lacrimal Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lacrimal Gland

Lacrimal Gland Adenocarcinoma

Adenocarcinoma Of Lacrimal Gland

Lacrimal System Cancer

Neoplasm Of Lacrimal System	Lacrimal System Neoplasm
Tumor Of The Lacrimal System

Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma

Acinar Cell Carcinoma

Acinic Cell Carcinoma	Acinic Cell Tumor
Carcinoma Acinar Cell	Carcinoma, Acinar Cell
Acinar Cell Tumor

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Apocrine Sweat Gland Neoplasm

Apocrine Tumor

Apocrine Neoplasm

Anus Basaloid Carcinoma

Basaloid Carcinoma Of The Anus

Anal Basaloid Carcinoma

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09250	NFIB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFIB	MGD	MGI:103188
Felis catus	NFIB	VGNC	VGNC:82494
Macaca mulatta	NFIB	VGNC	VGNC:75335
Rattus norvegicus	NFIB	RGD	RGD:62015
Bos taurus	NFIB	VGNC	VGNC:32039
Canis familiaris	NFIB	VGNC	VGNC:43776